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FRAG 176-191
Hexarelin
MK-677

Hexarelin: The Complete Guide to Dosage, Benefits, and Research in 2024

1.Frag 176-191 Dosage Chart | Quick Breakdown

Purpose Dosage Range Frequency Administration
General Use 51-2 mcg/kg 2-3x daily Subcutaneous injection
Metabolic Health 10-15 mg 1x daily Subcutaneous injection
Cardiovascular Health 2 mcg/kg 1-2x daily Intravenous/Subcutaneous
Research 100-200 mcg 2-3x daily Subcutaneous injection
Anti-Aging 1-2 mcg/kg 1-2x daily Subcutaneous injection

2. What is Hexarelin?

Hexarelin is a synthetic hexapeptide growth hormone secretagogue. Key points:

  • Chemical formula: C47H58N12O6

  • Molecular weight: 887.05 g/mol

  • Sequence: His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2

  • Developed as a more stable and potent analog of GHRP-6

  • Stimulates growth hormone release without significantly affecting other hormones

  • Half-life of about 70 minutes, longer than GHRP-6

Table of Contents

3. Hexarelin Mechanism of Action


Hexarelin works through several mechanisms:

  1. Binds to and activates the growth hormone secretagogue receptor (GHSR-1a)

  2. Stimulates the release of growth hormone from the pituitary gland

  3. Activates the PI3K/Akt pathway in the hippocampus

  4. Regulates nitric oxide synthesis and free radical production

  5. Triggers the CD36 scavenger receptor

  6. Influences cardiac function and morphology

  7. Modulates inflammatory responses and the autonomic nervous system

4. Research Applications and Potential Benefits of Hexarelin

Hexarelin and Cardiovascular Health

  • Improves left ventricular ejection fraction (LVEF) and cardiac output

  • Reduces wedge pressure in coronary artery disease patients

  • Inhibits cardiomyocyte apoptosis and promotes cell survival

  • Reduces cardiac fibrosis and attenuates left ventricular hypertrophy

Hexarelin and Muscle Growth

  • Enhances muscle growth and collagen production

  • Increases tendon and skeletal muscle matrix tissue strength

Hexarelin and Bone Density

  • Potential to increase bone mineral density

  • May be beneficial for osteoporosis

Hexarelin and Neuroprotection

  • Protects neurons from excessive intracellular calcium concentrations

  • Reduces inflammation in brain tissue

  • Potential benefits for neurodegenerative conditions

Hexarelin and Metabolic Health

  • Enhances lipid metabolism, especially in white fat cells

  • Improves hepatic insulin sensitivity

  • Increases formation of brown adipose tissue

Hexarelin and Anti-Aging

  • Potential to counteract age-related decline in growth hormone production

  • May improve skin elasticity and reduce signs of aging

5. Hexarelin Dosage Guide

Dosing Hexarelin for General Use

  • Typical dose: 1-2 mcg per kg of body weight

  • Administered 2-3 times daily

Dosing Hexarelin for Cardiovascular Health

  • Dose: 2 mcg per kg of body weight

  • Administered 1-2 times daily

Dosing Hexarelin for Research

  • Dose range: 100-200 mcg

  • Administered 2-3 times daily

Dosing Hexarelin for Anti-Aging

  • Dose: 1-2 mcg per kg of body weight

  • Administered 1-2 times daily

6. How to Mix and Administer Hexarelin

  1. Reconstitute lyophilized Hexarelin with bacteriostatic water

  2. Use sterile injection materials

  3. Calculate dosage based on body weight or research protocol

  4. Draw correct amount into syringe

  5. Administer via subcutaneous injection or as prescribed by research protocol

7. Hexarelin Administration Methods

Subcutaneous Injection

  • Most common method for research and general use

  • Inject into fatty tissue of abdomen or thigh

Intravenous Administration

  • Used in some cardiovascular research protocols

  • Requires medical supervision

8. Hexarelin Combinations and Interactions

Hexarelin + GHRH (e.g., Sermorelin)

  • May enhance growth hormone release synergistically

Hexarelin + Exercise

  • Potential to amplify muscle growth and recovery benefits

Always research potential interactions before combining substances.

9. Where to Buy Hexarelin Online | 2024 Edition

Hexarelin is primarily available for research purposes. It's crucial to source from reputable suppliers that provide certificates of analysis and third-party testing results.

10. Is Hexarelin Safe?

Generally considered to have a favorable safety profile in studies, but potential side effects include:

  • Transient increase in cortisol levels (at high doses)

  • Injection site reactions

  • Headache

  • Flushing

Long-term safety data in humans is limited. Use should be under medical supervision.

11. Is Hexarelin Legal?

  • Not approved by the FDA for human use

  • Legal status varies by country and jurisdiction

  • Often restricted to research or medical use

  • In the US, it's legal to possess for research purposes but not for human consumption

12. Hexarelin Storage and Handling

  • Store lyophilized powder at -20°C (-4°F)

  • Once reconstituted, store in refrigerator (2-8°C or 36-46°F)

  • Use within 30 days after reconstitution

  • Protect from light and excessive heat

  • Always use sterile techniques when handling

13. Frequently Asked Questions (FAQ)

How long does it take to see effects from Hexarelin?

Effects on GH levels can be seen within 30 minutes of administration, but changes in body composition may take several weeks to months.

 Can Hexarelin be used for bodybuilding?

While not approved for this purpose, some bodybuilders use Hexarelin for its potential to increase muscle mass and improve recovery.

How does Hexarelin compare to other GH secretagogues?

Hexarelin is considered more potent and stable than GHRP-6, with a longer half-life and potentially stronger effects on GH release.

 Are there any long-term risks associated with Hexarelin use?

 Long-term safety data is limited. Potential risks include disruption of natural GH production and possible effects on other hormonal systems.

14. Hexarelin Dosage | Final Verdict

Hexarelin shows promise as a potent growth hormone secretagogue with potential benefits for cardiovascular health, muscle growth, and anti-aging applications. The typical dosage range of 1-2 mcg/kg administered 2-3 times daily appears effective for most research applications. Its unique properties, including cardiovascular benefits and neuroprotective potential, make it an intriguing subject for further study.However, its use should be approached cautiously due to limited long-term human safety data and varying legal status worldwide. As with any experimental compound, thorough research and professional consultation are essential before use. The potential of Hexarelin in various health conditions warrants further investigation, particularly in larger, long-term human trials.

15. References

  1. Massoud AF, et al. (1996). The effects of repeated administration of hexarelin, a growth hormone releasing peptide, and growth hormone releasing hormone on growth hormone responsivity. Clinical Endocrinology, 44(5), 555-562.

  2. Rahim A, et al. (1994). Long-term treatment with hexarelin does not significantly affect pituitary GH responsiveness. Clinical Endocrinology, 41(2), 191-195.

  3. Angelino E, et al. (2015). The role of the growth hormone-releasing hormone/growth hormone/insulin-like growth factor-1 axis in the cardiovascular system. Current Cardiology Reviews, 11(3), 260-269.

  4. Mao Y, et al. (2013). Hexarelin treatment in male ghrelin knockout mice after myocardial infarction. Endocrinology, 154(10), 3847-3854.

  5. Kishimoto I, et al. (2009). Ghrelin and cardiovascular diseases. Journal of Cardiology, 54(2), 183-190.

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