Selank

Selank is a synthetic peptide drug developed in Russia. Key points:

• Composed of the tuftsin sequence (Thr-Lys-Pro-Arg) with an added Pro-Gly-Pro at the C-terminus
• Molecular formula: C33H55N11O9
• Molecular weight: 751.86 g/mol
• Developed by the Institute of Molecular Genetics of the Russian Academy of Sciences
• Approved for medical use in Russia for anxiety disorders
• Known for its anxiolytic and nootropic properties

Selank works through several mechanisms:

• 1 Binds to GABA receptors, potentially modulating GABAergic neurotransmission
• 2 Increases serotonin metabolism and affects serotonergic system
• 3 Elevates brain-derived neurotrophic factor (BDNF) levels
• 4 Modulates expression of interleukin-6 (IL-6) and other cytokines
• 5 Affects balance of T helper cell cytokines
• 6 Influences concentration of monoamine neurotransmitters (dopamine, norepinephrine)
• 7 May interact with enkephalins and affect opioid system

• Reduces symptoms of generalized anxiety disorder
• May help with panic disorders and social anxiety
• Shows efficacy comparable to benzodiazepines without side effects

• Improves learning and memory
• Enhances attention and mental clarity
• May have neuroprotective effects

• Increases stress resilience
• May help normalize sleep patterns
• Potential adaptogenic properties

• Affects cytokine production
• May enhance natural killer cell activity
• Potential antiviral properties

• Shows antidepressant-like effects in animal models
• May enhance the effects of traditional antidepressants

• Typical dose: 300-900 mcg per day
• Often divided into 1-3 doses
• Start with lower dose and titrate up as needed

• Typical dose: 300-600 mcg per day
• Usually administered 1-2 times daily
• May be used as needed for acute cognitive boost

• Dose range: 300-900 mcg per day
• Can be administered 1-3 times daily
• May be used acutely before stressful events

• Dose range: 250-1000 mcg per day
• Frequency depends on research protocol
• Higher doses may be used for specific studies

Selank is typically available as a pre-mixed nasal spray. For research purposes:

• 1 If using lyophilized powder, reconstitute with bacteriostatic water or saline
• 2 Use 1 ml of water per 10 mg of Selank powder
• 3 Gently swirl to mix, avoid shaking
• 4 Calculate dosage based on concentration (e.g., 0.15% solution = 150 mcg per drop)

• Most common method
• Tilt head back slightly
• Insert dropper or spray nozzle into nostril
• Administer prescribed dose
• Allow solution to absorb through nasal mucosa

• Use insulin syringe (29-31 gauge)
• Inject into fatty tissue of abdomen or thigh
• Rotate injection sites

• May enhance cognitive effects of racetams
• Potential synergy with cholinergic compounds

• May potentiate effects of SSRIs
• Could reduce side effects of traditional antidepressants

• May enhance effects of anxiolytic herbs (e.g., ashwagandha)
• Potential to reduce required dose of benzodiazepines

Always research potential interactions before combining substances.

Selank is available through specialized pharmacies in Russia. For research purposes, it may be obtained from reputable peptide suppliers. Always ensure third-party testing and proper documentation.

Generally considered to have a favorable safety profile:

• No significant side effects reported in clinical trials
• No addiction or withdrawal symptoms observed
• Does not impair cognitive function or motor skills

Potential minor side effects may include:

• Nasal irritation (with intranasal use)
• Mild headache
• Dizziness (rare)

Long-term safety data beyond several months of use is limited.

• Approved for medical use in Russia
• Not approved by FDA or EMA for human use
• Legal status varies by country
• Often available as a research chemical, not for human consumption
• Not controlled under the Controlled Substances Act in the US

• Store lyophilized powder at room temperature (20-25°C or 68-77°F)
• Once reconstituted, store in refrigerator (2-8°C or 36-46°F)
• Use within 30 days after reconstitution
• Keep out of reach of children
• Keep out of reach of children

Effects may be noticeable within 5-15 minutes of administration, with peak effects occurring within 2-3 hours.

While some studies have used Selank for up to 3 months, long-term safety data is limited. Consult a healthcare professional for extended use.

Unlike benzodiazepines, Selank is not associated with sedation or drowsiness, making it suitable for daytime use.

While some research suggests potential antidepressant effects, Selank is primarily studied for anxiety. More research is needed for its use in depression.

Selank shows promise as an anxiolytic and nootropic peptide with a favorable safety profile compared to traditional anxiety medications. The typical dosage range of 300-900 mcg per day, depending on the application, appears effective for most research purposes. Its unique mechanism of action, combining anxiolytic effects with potential cognitive enhancement, makes it an intriguing subject for further study.However, its use should be approached cautiously due to limited long-term safety data and varying legal status worldwide. As with any experimental compound, thorough research and professional consultation are essential before use. The potential of Selank in anxiety disorders, cognitive enhancement, and stress management warrants further investigation, particularly in larger, long-term human trials.

• 1 Kozlovskaya MM, et al. (2003). Selank and short peptides of the tuftsin family in the regulation of adaptive behavior in stress. Neuroscience and Behavioral Physiology, 33(9), 853-860.
• 2 Kolomin T, et al. (2013). Transcriptomic effects of tuftsin-like peptides in the hippocampus of rats. Molecular Genetics and Genomics, 288(7-8), 353-360.
• 3 Medvedev VE, et al. (2015). Optimization of the treatment of anxiety disorders with selank. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 115(6), 33-40.
• 4 Semenova TP, et al. (2008). Experimental study of effects of selank on learning and memory. Bulletin of Experimental Biology and Medicine, 145(5), 569-572.
• 5 Eremin KO, et al. (2005). Influence of Semax on the level of monoamines and their metabolites in the brain of rats with different phenotypes of emotional and stress response. Bulletin of Experimental Biology and Medicine, 139(5), 523-526.
• 6 Ashmarin IP, et al. (2008). Natural and hybrid ("chimeric") stable regulatory glyproline peptides. Pathophysiology, 15(3), 203-209.
• 7 Volkova A, et al. (2016). Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Frontiers in Pharmacology, 7, 31.
• 8 Czabak-Garbacz R, et al. (2006). Influence of long-term treatment with tuftsin analogue TP-7 on the anxiety-phobic states and body weight. Pharmacological Reports, 58(4), 562-567.
• 9 Telegina DV, et al. (2013). Influence of Selank on Systems of GABA and Serotonin in the Rat Brain. Bulletin of Experimental Biology and Medicine, 155(3), 335-337.
• 10 Kolik LG, et al. (2012). Anxiolytic effects of selank in different animal models of anxiety. Bulletin of Experimental Biology and Medicine, 152(3), 335-338.