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5-Amino-1MQ: The Complete Guide to Dosage, Benefits, and Research in 2024

1. 5-Amino-1MQ Dosage Chart | Quick Breakdown

Purpose Dosage Range Frequency Administration
General Use 50-150 mg 1-3x daily Oral capsules
Weight Loss 100-150 mg 1-2x daily Oral capsules
Research 10-150 mg/kg/day As per protocol Oral/Injectable (animal studies)

2. What is 5-Amino-1MQ?

5-Amino-1MQ is a small molecule drug designed to inhibit the enzyme nicotinamide N-methyltransferase (NNMT). Key points:

  • Chemical formula: C10H11N2+

  • Structure: Quinoline ring with an amino group at position 5 and a methyl group at position 1

  • Developed as a selective NNMT inhibitor

  • Primarily studied for its effects on metabolism and weight loss

  • Not FDA-approved; currently used in research settings

Table of Contents

3. 5-Amino-1MQ Mechanism of Action

5-Amino-1MQ works through several mechanisms:

  1. Inhibits NNMT, an enzyme predominantly active in fat tissue

  2. Increases nicotinamide adenine dinucleotide (NAD+) levels

  3. Activates sirtuin-1 (SIRT1), also known as "the longevity gene"

  4. Enhances cellular metabolism and energy expenditure

  5. Promotes fat burning while preserving muscle mass

  6. Regulates energy expenditure in fat cells

  7. May increase NAD+ and S-adenosyl methionine (SAM) concentrations in fat cells

4. Research Applications and Potential Benefits of 5-Amino-1MQ

5-Amino-1MQ and Weight Loss

  • Promotes fat loss while preserving muscle mass

  • May reverse diet-induced obesity

  • Enhances metabolic rate and fat burning

5-Amino-1MQ and Metabolic Health

  • Potential treatment for type 2 diabetes and metabolic syndrome

  • May improve insulin sensitivity

  • Could lower cholesterol levels and improve blood sugar control

5-Amino-1MQ and Muscle Health

  • Enhances aged muscle regeneration

  • May promote muscle growth and recovery

  • Potential benefits for sarcopenia (age-related muscle loss)

5-Amino-1MQ and Cancer

  • Shows promise in combating various cancer types

  • May disrupt energy supply to cancer cells

  • Potential to enhance effectiveness of cancer therapies

5-Amino-1MQ and Anti-Aging

  • Activates SIRT1, associated with longevity

  • May have anti-inflammatory properties

  • Potential to improve overall healthspan

5. 5-Amino-1MQ Dosage Guide

Dosing 5-Amino-1MQ for General Use

  • Typical dose: 50-150 mg per day

  • Often divided into 1-3 doses

Dosing 5-Amino-1MQ for Weight Loss

  • Higher dose: 100-150 mg per day

  • Usually divided into 1-2 doses

Dosing 5-Amino-1MQ for Research

  • Dose range in animal studies: 10-150 mg/kg/day

  • Human equivalent doses not established

6. How to Mix and Administer 5-Amino-1MQ

5-Amino-1MQ is typically available in pre-measured capsules:

  • No mixing required for oral capsules

  • For research purposes, may be reconstituted with appropriate solvents

  • Always follow manufacturer's instructions for handling and administration

7. 5-Amino-1MQ Administration Methods

Oral Administration

  • Most common method for human use

  • Take capsules on an empty stomach

  • May be taken once daily or divided into multiple doses

Injectable Administration (Research Only)

  • Used in animal studies

  • Not typically used in human applications

8. 5-Amino-1MQ Combinations and Interactions

Limited data on combinations. Potential synergies with:

  • NAD+ boosters

  • Other metabolic enhancers

  • Exercise regimens for enhanced fat loss

Always research potential interactions before combining substances.

9. Where to Buy 5-Amino-1MQ Online | 2024 Edition

5-Amino-1MQ is primarily available for research purposes. It's crucial to source from reputable suppliers that provide certificates of analysis and third-party testing results.

10. Is 5-Amino-1MQ Safe?

Generally considered to have a favorable safety profile in animal studies:

  • No significant adverse effects reported in preclinical trials

  • Human safety data is limited

Potential side effects may include:

  • Nausea

  • Headache

  • Increased appetite (due to increased metabolic rate)

Long-term safety data in humans is not yet available.

11. Is 5-Amino-1MQ Legal?

  • Not approved by the FDA for human use

  • Legal status varies by country and jurisdiction

  • Often restricted to research or medical use

  • In the US, it's legal to possess for research purposes but not for human consumption

  • Always check local laws before purchasing or using 5-Amino-1MQ

12. 5-Amino-1MQ Storage and Handling

  • Store in a cool, dry place away from direct light

  • Keep at room temperature (20-25°C or 68-77°F)

  • Protect from moisture

  • Keep out of reach of children

  • Use within the expiration date

13. Frequently Asked Questions (FAQ)

How long does it take to see effects from 5-Amino-1MQ?

Effects may vary, but some users report noticeable changes in energy levels and metabolism within 2-4 weeks of consistent use.

Can 5-Amino-1MQ be used for bodybuilding?

While not primarily designed for bodybuilding, its potential to preserve muscle mass during fat loss may be beneficial for body composition goals.

Is 5-Amino-1MQ safe for long-term use?

 Long-term safety data in humans is limited. More research is needed to establish its safety profile for extended use.

How does 5-Amino-1MQ compare to other weight loss supplements?

5-Amino-1MQ's unique mechanism of NNMT inhibition sets it apart from many traditional weight loss supplements, potentially offering metabolic benefits beyond simple calorie reduction.

14. 5-Amino-1MQ Dosage | Final Verdict

  • 5-Amino-1MQ shows promise as a novel compound for metabolic health, weight management, and potentially anti-aging applications. The typical dosage range of 50-150 mg per day appears effective for most research applications. Its unique mechanism of NNMT inhibition offers a new approach to tackling obesity and metabolic disorders.However, its use should be approached cautiously due to limited long-term human safety data and varying legal status worldwide. As with any experimental compound, thorough research and professional consultation are essential before use. The potential
    of 5-Amino-1MQ in weight management, metabolic health, and age-related conditions warrants further investigation, particularly in larger, long-term human trials.

15. References

  1. Neelakantan H, et al. (2019). Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochemical Pharmacology, 164, 165-180.

  2. Kannt A, et al. (2018). A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders. Scientific Reports, 8(1), 3660.

  3. Kraus D, et al. (2014). Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature, 508(7495), 258-262.

  4. Hong S, et al. (2015). Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization. Nature Medicine, 21(8), 887-894.

  5. Ulanovskaya OA, et al. (2013). NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink. Nature Chemical Biology, 9(5), 300-306.

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