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Melanotan II: The Complete Guide to Dosage, Benefits, and Research in 2024

1.Melanotan II Dosage Chart | Quick Breakdown

Purpose Dosage Range Frequency Administration
Tanning 0.01-0.03 mg/kg Every other day Subcutaneous injection
Sexual Dysfunction 0.025-0.03 mg/kg As needed Subcutaneous injection
Research 0.01-0.05 mg/kg As per protocol Subcutaneous injection

2. What is Melanotan II?

Melanotan II is a synthetic analogue of the peptide hormone alpha-melanocyte-stimulating hormone (α-MSH). Key points:

  • Chemical formula: C50H69N15O9

  • Molecular weight: 1024.2 g/mol

  • Sequence: Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH2

  • Cyclic heptapeptide structure

  • Developed at the University of Arizona in the 1980s

  • Not approved for human use by regulatory agencies

Table of Contents

3. Melanotan II Mechanism of Action

Melanotan II works through several mechanisms:

  1. Binds to and activates melanocortin receptors (MC1R, MC3R, MC4R, MC5R)

  2. Stimulates melanogenesis in skin melanocytes

  3. Increases production of eumelanin, leading to skin darkening

  4. Affects sexual arousal through central nervous system effects

  5. Influences appetite and metabolism via MC4R activation

  6. May have effects on the cardiovascular and immune systems

4. Research Applications and Potential Benefits of Melanotan II

Melanotan II and Tanning

  • Induces melanogenesis without UV exposure

  • Potential for reducing UV-induced skin damage

  • May lower risk of skin cancer (theoretical, not proven)

Melanotan II and Sexual Dysfunction

  • Potential treatment for erectile dysfunction

  • May increase sexual arousal in both men and women

Melanotan II and Appetite Suppression

  • Possible application in weight management

  • Affects food intake through MC4R activation

Melanotan II and Skin Conditions

  • Potential treatment for vitiligo and other hypopigmentation disorders

  • May have applications in photoprotection

5.  Melanotan II Dosage Guide

Dosing Melanotan II for Tanning

  • Starting dose: 0.01 mg/kg

  • Maintenance dose: 0.02-0.03 mg/kg

  • Administered every other day for 2-3 weeks

Dosing Melanotan II for Sexual Dysfunction

  • Typical dose: 0.025-0.03 mg/kg

  • Administered as needed, 1-2 hours before sexual activity

Dosing Melanotan II for Research

  • Dose range: 0.01-0.05 mg/kg

  • Frequency depends on research protocol

6.How to Mix and Administer Melanotan II

  • Reconstitute lyophilized Melanotan II with bacteriostatic water

  • Use sterile injection materials

  • Calculate dosage based on body weight

  • Draw correct amount into insulin syringe

  • Administer via subcutaneous injection

7.Melanotan II Administration Methods

Subcutaneous Injection

  • Most common method

  • Inject into fatty tissue of abdomen or thigh

  • Rotate injection sites

Nasal Spray

  • Less common, but used by some

  • May have lower bioavailability compared to injection

8. Melanotan II Combinations and Interactions

Melanotan II + Sunlight/UV exposure

  • May enhance tanning effects

  • Caution advised due to potential increased skin cancer risk

Melanotan II + PDE5 inhibitors

  • Potential for enhanced effects on erectile function

  • Caution advised due to risk of priapism

Always research potential interactions before combining substances.

9. Where to Buy Melanotan II Online | 2024 Edition

Melanotan II is not approved for human use and is primarily available for research purposes. It's crucial to note that purchasing or using Melanotan II for personal use is not recommended due to safety and legal concerns.

10.  Is Melanotan II Safe?

Melanotan II is associated with numerous safety concerns:

  • Changes in size and pigmentation of existing moles

  • Potential increased risk of melanoma

  • Renal dysfunction and rhabdomyolysis

  • Cardiovascular effects (e.g., increased blood pressure)

  • Nausea, facial flushing, and fatigue

  • Potential for abuse and addiction

  • Risk of contamination in unregulated products

Long-term safety data in humans is limited, and use is not recommended.

11. Is Melanotan II Legal?

  • Not approved by the FDA or other major regulatory agencies for human use

  • Legal status varies by country and jurisdiction

  • Often restricted to research use only

  • Sale for human consumption is illegal in many countries

  • Possession may be legal in some areas, but use is strongly discouraged

12. Melanotan II Storage and Handling

  • Store lyophilized powder at -20°C (-4°F)

  • Once reconstituted, store in refrigerator (2-8°C or 36-46°F)

  • Use within 30-60 days after reconstitution

  • Protect from light and excessive heat

  • Always use sterile techniques when handling

13. Frequently Asked Questions (FAQ)

How long does it take to see tanning effects from Melanotan II?

Effects may be noticeable within 5-7 doses, with maximum effect typically seen after 2-3 weeks of regular use.

Can Melanotan II be used safely for long-term tanning?

 Long-term use is not recommended due to potential health risks and lack of safety data.

Does Melanotan II protect against skin cancer?

While it may theoretically reduce UV damage, there's no evidence that it protects against skin cancer, and it may increase the risk of melanoma.

Are there any alternatives to Melanotan II for tanning?

Safer alternatives include gradual self-tanning products and controlled UV exposure with proper sun protection.

14. Ipamorelin Dosage | Final Verdict

While Melanotan II has shown potential effects on tanning and sexual function, its use is associated with significant risks and is not recommended for human use outside of controlled research settings. The lack of regulation, potential for serious side effects, and unknown long-term consequences make it a dangerous substance for personal use. Individuals seeking tanning or treatment for sexual dysfunction should consult with healthcare professionals for safe, approved alternatives.

15. References

  1. Brennan R, et al. (2017). Melanotan II use in the general population. BMJ Case Rep, 2017, bcr2017221301.

  2. Langan EA, et al. (2010). Melanotan: the perils of an unlicensed drug. BMJ, 340, c2305.

  3. Nelson ME, et al. (2019). The abuse liability and clinical pharmacokinetics of intranasal melanotan-II. Drug Alcohol Depend, 201, 89-96.

  4. Ong S, Bowling J. (2012). Melanotan-associated melanoma in situ. Australas J Dermatol, 53(4), 301-302.

  5. Therapeutic Goods Administration. (2018). Scheduling delegates' interim decisions and invitation for further comment: ACCS/ACMS, November 2017.

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